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Technology

Our Technology

OTR3® technology stems from understanding the central role of the extracellular matrix in the body’s continued ability to replace a dying cell by another identical cell within a tissue or organ.

This continuous renewal process is regulated by bespoke signals of the extra cellular space around the cells. These signals are stored, protected, and positioned on a family of large polysaccharides called Heparan Sulfates, that act as a the scaffolding of the extra cellular matrix.

In cases of injury, specific enzymes called glycanases destroy Heparan Sulfates, that no longer protect the bespoke signals. Other enzymes called proteases then destroy bespoke signals along with other endogenous factors of the extracellular matrix.

The injury creates an “emergency” response that activates the circulating and inflammatory cells towards the injured part of the body. These "emergency" cells produce "emergency" signals that then ensure the reparation of the injury but may leave marks, scars or fibrosis, all leading to a loss of tissue quality.

OTR3® has developed Heparan Sulfate mimetic polymers, capable of replacing the destroyed Heparan Sulfates. New Heparan Sulfate mimetic polymers reconstruct the extra cellular matrix scaffolding around the cells, thus allowing the natural bespoke signals to reposition themselves in their original configuration. This reorganization of the proper signals recreates a microenvironment favorable for the renewal of cells identical to those destroyed with the injury. The natural process of regeneration is then restored to its full potential.

These polymers have thus been called regenerating tissue agents (ReGeneraTing Agents or RGTA®) and OTR3® has established the structural properties of the polymers that are best suited to perform these functions. This know-how is at the heart of the intellectual property and expertise of OTR3®.


How RGTA® Works

RGTA® Action Mechanism:

When introduced in the injured site, the RGTA® technology:

- Replaces degraded Heparan Sulfates
- Binds to proteins of the extracellular matrix such as collagen, elastin, and laminin etc…
- Reconstitutes the matrix architecture
- Becomes an anchorage and stocking site for cellular communication factors or "signals"
- Protects matrix proteins and endogenous factors from degradation by proteases

RGTA® reconstitutes the extracellular matrix environment allowing damaged tissue to regenerate.