Key developments
OTR3 focuses on key advances, both clinical and preclinical, fulfilling our mission to explore the most promising indications of RGTA® technology.
The potential benefit of these OTR3 studies has been confirmed by numerous awards and grants (H2020 SME Instrument, Medicen Label, ANR, INCA).
Preclinical studies
Preclinical studies
Regenerative Medicine
Funding
Matrix Therapy to Protect and Regenerate Brain from Tauopathy-Related Disorders
ANR-24-CE52-2652: https://anr.fr/Projet-ANR-24-CE52-2652
Stroke Management
Funding
Stroke management through RGTA®: SMR
H2020 811729
Acute ischemic stroke
Funding
La thérapie matricielle pour l’ischémie cérébrale : une nouvelle opportunité pour protéger le tissu cérébral en souffrance et pour promouvoir sa régénération ?
ANR-15-CE18-0029 MAESTRO: https://anr.fr/Projet-ANR-15-CE18-0029
Acute ischemic stroke
Funding
A matrix therapy to optimize MSC-derived extracellular vesicles for brain protection and repair after ischemia
ANR-21-CE18-0029: https://anr.fr/Projet-ANR-21-CE18-0029
Publications
A heparan sulfate-based matrix therapy reduces brain damage and enhances functional recovery following stroke. 2018.
Brain protection after radiotherapy
Funding
Matrix Therapy against Radiotherapy-Induced Brain damage and Cognitive deficits (Brain-MATRiX)
INCa-Brain-Matrix: 2021-068 https://www.e-cancer.fr/Institut-national-du-cancer/Appels-a-projets/Appels-a-projets-resultats/PLBIO2021
Alzheimer’s disease and tauopathies
Publications
Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration. 2022
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. 2013
Acute lung diseases
Funding
Heparan Sulfate Mimetics as a New Therapy for Acute Pulmonary Lesions
ANR-22-CE18-0013 / https://anr.fr/Projet-ANR-22-CE18-0013
Publications
Heparan Sulfate Mimetics as a New Therapy for Acute Pulmonary Lesions.
Radiotherapy treatment
Funding
Synthèse sonoélectrochimique de nanoparticules de phosphate de calcium pour hydrogels injectables
ANR-18-CE18-0014: https://anr.fr/Projet-ANR-18-CE18-0014
Publications
Heparan-mimetics: Potential agents of tissue regeneration for bone and periodontal therapies. 2021
Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice. 2018
Glycosaminoglycan mimetic associated to human mesenchymal stem cell-based scaffolds inhibit ectopic bone formation, but induce angiogenesis in vivo. 2013
Kinetic study of early regenerative effects of RGTA11, a heparan sulfate mimetic, in rat craniotomy defects.
Type-2 Diabetes
Funding
Développement de molécules libératrices de monoxyde de carbone conjuguées à des polysaccarides pour cibler le tissu adipeux dans l’obésité.
ANR-19-CE18-0032: https://anr.fr/Projet-ANR-19-CE18-0032
Publications
DEVELOPMENT OF CARBON MONOXIDE-RELEASING MOLECULES CONJUGATED TO POLYSACCHARIDE CARRIERS TARGETING ADIPOSE TISSUE FOR THE TREATMENT OF OBESITY
Skin lesions
Funding
Skin tissue engineering and regenerative medicine: from skin repair to regeneration
H2020-MSCA-ITN-2020-SkinTerm-955722
Publications
Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration
Periodontitis
Publications
A new approach to treat tissue destruction in periodontitis with chemically modified dextran polymers. 2003
Periodontitis destructions are restored by synthetic glycosaminoglycan mimetic. 2006
ReGeneraTing agents matrix therapy regenerates a functional root attachment in hamsters with periodontitis. 2011
Periodontal reconstruction by heparan sulfate mimetic-based matrix therapy in Porphyromonas gingivalis-infected mice. 2018
Heparan-mimetics: Potential agents of tissue regeneration for bone and periodontal therapies. 2021
Cornea lesions
Available soon…
